PDS5A Antibody, Biotin conjugated

Code CSB-PA643713LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PDS5A Polyclonal antibody
Uniprot No.
Target Names
PDS5A
Alternative Names
Cell proliferation inducing protein 54 antibody; Cell proliferation-inducing gene 54 protein antibody; KIAA0648 antibody; PDS5; regulator of cohesion maintenance; homolog A (S. cerevisiae) antibody; PDS5A antibody; PDS5A_HUMAN antibody; PIG54 antibody; SCC-112 antibody; SCC112 antibody; Sister chromatid cohesion protein 112 antibody; Sister chromatid cohesion protein PDS5 homolog A antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Sister chromatid cohesion protein PDS5 homolog A protein (2-134AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Gene References into Functions
  1. These results provide the first evidence indicating a tumor suppressor role of SA1 in early colon carcinogenesis PMID: 27549371
  2. By interacting with a unique domain of Esco1, Pds5 recruits Esco1 to chromatin-bound cohesin complexes to form cohesion. PMID: 26051894
  3. The data show a downregulation of proliferation-associated host gene PDS5A and suggest a role of PDS5A in HIV-1-induced cellular pathogenesis but not viral replication. PMID: 21865657
  4. Data show that the siRNA-mediated knockdown of Pds5A affects sister chromatid cohesion but does not influence mitotic checkpoint function or the proliferation and survival of glioblastoma multiforme cells. PMID: 21069257
  5. Findings suggest that the SCC-112 gene expression is likely to be associated with normal cell growth and proliferation. PMID: 15019998
  6. SCC-112 improve cell proliferation and contributes to tumorigenesis by interacting with p63 and promoting cell cycling. PMID: 17846787

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Subcellular Location
Nucleus.
Protein Families
PDS5 family
Tissue Specificity
Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue. Isoform 2 is expressed in kidney.
Database Links

HGNC: 29088

OMIM: 613200

KEGG: hsa:23244

STRING: 9606.ENSP00000303427

UniGene: Hs.331431

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